Justin Sing

Hi! My name is Justin, I'm a PhD student at the University of Toronto under the supervision of Dr. Hannes Röst. My research focus centers on personalized medicine and advancing methods development for mass spectrometry proteomics. I strongly believe in open-source and open-science, and actively contribute to global collaborative initiatives to enhance the research community.

– "To understand ourselves means to reflect on time. But to understand time we need to reflect on ourselves. - Carlo Rovelli".

Asterisks (*) indicate equal contributions

Preprint Publications

• Diagnostic Potential of Shallow Depth Gut Metagenomics Sequencing for Atherosclerotic Cardiovascular Disease Risk Stratification.
  Sing, J. C.*, Whitley, O., & Davis, S. (2023). BioRxiv. doi.org/10.1101/2023.10.02.560614

Publications

• pyOpenMS-viz: Streamlining Mass Spectrometry Data Visualization with pandas.
  Sing, J. C.*, Charkow, J., Walter, A., et. al., Sachsenberg, T., & Roest, H. L. (2024). Journal of Proteome Research. doi.org/10.1021/acs.jproteome.4c00873

• OpenMS WebApps: Building User-Friendly Solutions for MS Analysis.
  Muller, T., Siraj, A., ... , Sing, J. C., ..., et. al., Sachsenberg, T. (2024). Journal of Proteome Research. doi.org/10.1021/acs.jproteome.4c00872

• MassDash: A Web-based Dashboard for Targeted Mass Spectrometry Visualization.
  Sing, J. C.*, Charkow, J., AlHigaylan, M., Horecka, I., Xu, L., & Roest, H. L. (2024). Journal of Proteome Research. doi.org/10.1021/acs.jproteome.4c00026

• Longitudinal Cytokine and Multi-Modal Health Data of an Extremely Severe ME/CFS Patient with HSD Reveals Insights into Immunopathology, and Disease Severity
  Jahanbani, F., Sing, J. C.*, Maynard, R. D., Jahanbani, S., Dafoe, J., Dafoe, W., Jones, N., Wallace, K. J., Rastan, A., Rost, H., Maecker, H., Snyder, M. P., Davis, R. W. (2024). Frontiers in Immunology. doi.org/10.3389/fimmu.2024.1369295

• OpenMS 3 Expands the Frontiers of Open-Source Computational Mass Spectrometry.
  Sachsenberg, T., Pfeuffer, J., Bielow, C., Wein, S., Jeong, K., Netz, E., Walter, A., Alka, O., Nilse, L., Colaianni, P., McCloskey, D., Kim, J., Rosenberger, G., Bichmann, L., Walzer, M., Veit, J., Boudaud, B., Bernt, M., Patikas, N., … Sing, J. C. … Kohlbacher, O. (2024). Nature Methods. doi.org/10.1038/s41592-024-02197-7

• Proteometabolomics of initial and recurrent glioblastoma highlights an increased immune cell signature with altered lipid metabolism
  Cosenza-Contreras, M., Schäfer, A., Sing, J. C., et al., Röst, H., Arnoux, A., Bartsch, J., & Schilling, O. (2024). Neuro-Oncology. doi.org/10.1093/neuonc/noad208

• Achieving quantitative reproducibility in label-free multisite DIA experiments through multirun alignment.
  Gupta, S., Sing, J. C.*, & Röst, H. L. (2023). Nature Communications doi.org/10.1038/s42003-023-05437-2

• Phenotypic characteristics of peripheral immune cells of myalgic encephalomyelitis/chronic fatigue syndrome via transmission electron microscopy: A pilot study.
  Jahanbani, F., Maynard, R. D., Sing, J. C., Jahanbani, S., Perrino, J. J., Spacek, D. V., Davis, R. W., & Snyder, M. P. (2022). PLOS ONE, 17(8). doi.org/10.1371/journal.pone.0272703

• Improving phosphoproteomics profiling using data-independent mass spectrometry.
  Srinivasan, A., Sing, J. C.*, Gingras, A.-C., & Röst, H. L. (2022). Journal of Proteome Research, 21(8), 1789–1799. doi.org/10.1021/acs.jproteome.2c00172

• DrawAlignR: An interactive tool for across run chromatogram alignment visualization.
  Gupta, S., Sing, J.*, Mahmoodi, A., & Röst, H. (2020). PROTEOMICS, 20(21–22). doi.org/10.1002/pmic.201900353